Showing posts with label biochemistry. Show all posts
Showing posts with label biochemistry. Show all posts

9/16/2012

Operators and Promoters: The Story of Molecular Biology and Its Creators Review

Operators and Promoters: The Story of Molecular Biology and Its Creators
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Hatch Echols was a well-known biologist. He spent years working on a personal history of his field. After his untimely death, his widow completed the manuscript. This book is the result. It is a history of molecular biology from about 1948 to about 1990. By molecular biology he means the attempt to understand biology using the tools of physics and chemistry. It is a superb book, as makes a fine compiment to the OTHER definitive history of molecular biology, Horace Freeland Judson's "Eighth Day of Creation". Judson's 1979(I think) book was a detailed account of three or four episodes in molecular biology, and stopped at 1970. Echols'book gives a much broader overview, focusing on the questions that arose and the people who answered them. The margins are graced by line drawings of the the major actors, done by the author. The result is a fine account of both the science (briefly) and those who made it. Most of the participants were his friends, and it shows. On the other hand, unlike most books, I am unaware of any animosity or basic unfairness towards any of the participants. Those of you looking for revelations of scandal had best look elsewhere. This is an idyll of discovery. Having studied the subject through textbooks, I enjoyed finding out about the twist and turns, the false starts and blind alleys and leaps in the dark that really lay behind the development of the most exciting science of the last half of the twentieth century. Highly recommended.
This book seems to be languishing in obscurity, and I think Judson's book is out of print. This is deplorable. Another reason to purchase it is because feel Operators and Promoters is a good book to dip into and read a few chapters here and a few there, so you will want to have a copy about the house.
Worth purchasing? Definitely

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7/24/2012

Molecular Biology of the Gene, Fifth Edition Review

Molecular Biology of the Gene, Fifth Edition
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I am a layman with a serious interest in biology. I read science news, especially in Nature and Scientific American, and I often find that I don't have enough background to understand articles at the level at which I want to understand them. I bought this book hoping to get that background, and I wasn't disappointed.
For example, once the human genome was sequenced, it appeared that there were far too few genes for an organism as complex as ourselves. But investigation shows that most genes occur in segments and that the messenger RNA must be cut and spliced before the protein can be formed. Often there are two or more ways the RNA may be spliced, so that one gene can specify more than one protein. Another problem is that the genome seemed to consist mostly of sections that don't code for proteins; these were called "junk". But it turns out that some "junk" DNA codes for RNA sequences that have catalytic and regulatory roles, roles which used to be considered the bailiwick of proteins alone. Articles about topics such as these used to confuse me thoroughly, but after reading this book I find them much clearer.
This book benefits from a great many illustrations and I recommend that you go through each one as you would a worked problem in a math text. Observe how the pieces fit together, how a particular group of atoms enhances or inhibits a reaction. The practice will help you to understand other things you will read later.
I called this a "reference" for good reason: I assume that I will come across many future articles which will send me back to it to fill in some background.
[Added 4 July 2006] As I assumed when I first wrote this review, I have used it for reference. I have read several books about what I call "enhanced evolution", where mechanisms that go beyond simple point mutations speed up evolution by providing more variation. For example, gene regulation, alternate splicing, and gene duplication all play important roles. I have surprised myself by remembering more than I expected to (thanks to the clarity of this book) but I have still used it for clarification.

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The long-awaited new edition of James D. Watson's classic text, Molecular Biology of the Gene, has been thoroughly revised and is published to coincide with the 50th anniversary of Watson and Crick's paper on the structure of the DNA double-helix. Twenty-one concise chapters, co-authored by five highly respected molecular biologists, provide current, authoritative coverage of a fast-changing discipline, giving both historical and basic chemical context. Divided into four parts: Genetics and Chemistry, Central Dogma, Regulation, and Methods. For college instructors, students, and anyone interested in molecular biology and genetics.

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4/03/2012

Medical Terminology: The Language of Health Care Review

Medical Terminology: The Language of Health Care
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I bought this book for a class, ended up dropping it (before it started), and decided to study the book anyway. This book is very thorough; it has a ton of information in it and is good about explaining the prefixes and suffixes and roots of the terms. They really break down each word to make sure you understand it. They also have actual photos of several different skin disorders and things of that nature, which I found to be useful too.

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Now students can learn medical terminology in its proper context—in documenting patient care. The text teaches students APPLIED terminology, demonstrating exactly how medical terminology is used in the clinical practice setting. Willis' Medical Terminology features COMPLETE records with patient history included. Completely unique, the fourth chapter teaches basic communication between professionals, including physician's orders and prescriptions, plus..."Ancient Artifacts" with colorful etymologies and historical backgrounds for commonly used terms.An entire chapter focuses on time management, sensory mnemonics, and using flash cards—information unique to this text. Helpful appendices include an index of term components, abbreviations and symbols, answers to exercises and a listing of commonly prescribed drugs.In addition to the best medical terminology available for students, Willis' Medical Terminology gives instructors a range of options for using the material:The TextThe Instructor's GuidePronunciation Audio Tapes OverheadsComputerized Test Bank

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2/21/2012

Peptide Nucleic Acids, Morpholinos and Related Antisense Biomolecules (Medical Intelligence Unit) Review

Peptide Nucleic Acids, Morpholinos and Related Antisense Biomolecules (Medical Intelligence Unit)
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This is the standard book in this field of research. A compilation of what is known about these synthetic nucleic acid analogues that no researcher in the field should be without.

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This volume is unique to the existing literature in the Peptide Nucleic Acid field, in that it focuses on comparing and contrasting PNA with other available oligonucleotide homologues and considers areas in which these biomolecules could be profitably applied to clinical and diagnostic applications. Part I of the book addresses comparative strengths and weaknesses of various nucleoside homologues. Part II of the book addresses specific translational or clinical applications for PNA and related antisense biomolecules. The editors have succeeded in presenting a balanced yet broad view of the methods available for gene targeting and modification.

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2/14/2012

Healing as Vocation: A Medical Professionalism Primer (Practicing Bioethics) Review

Healing as Vocation: A Medical Professionalism Primer (Practicing Bioethics)
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This is a thoughtful review of healthcare providers talking about more than just their role to heal biological but the whole person.

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This collection of essays provides educators in medicine and the health sciences an illuminating and challenging introduction to professionalism. The book takes a practical approach toward this topic, looking at what professionalism means, for the individual physician's relationship to his or her patients, to the medical profession as a whole, and to society at large. Written by leading scholars and thinkers in the area of professionalism in medicine, contributors provide a well-rounded analysis of this important topic. Although the intended audience is primarily physicians, medical students and residents, the book is a suitable primer for pre-professional health care students as well.

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12/19/2011

Medical Virology, Fourth Edition Review

Medical Virology, Fourth Edition
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As I have made out in my title, this is the best way I can describe this book. Its small size contradicts its vast amount of information within. With respect to the other reviewer the book I find is excellent at delivering highly detailed information in the fewest words - cutting to the chase - however like the other reviewer comments, its detail can be off putting without sufficient back up by other texts. In this respect the book is probably best thought of as reference material for instant access to cutting edge information on viruses. The book also has sections that individually deal with the virus families and allow the reader to quickly access information regarding viruses belonging to each family, which is particularly useful considering the quagmire of virus names.

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Medical Virology first appeared in 1970 and was immediately hailed as a classic. The Fourth Edition has been completely updated, substantially rewritten, and considerably expanded. Acknowledging that today's students possess a more sophisticated background of molecular and cellular biology, the book is pitched a little higher than was the third edition. Nevertheless, it maintains the exceptionally high standards of the three previous editions, including the now famous user-friendly style. Hundreds of instructive diagrams and succinct tables smooth the path for the reader. Extensive lists of recent authoritative reviews at the end of each of the 36 chapters simplifies the reader's entry into the scientific literature. Throughout, the focus is on fundamental principles, mechanisms and basic facts, rather than on overwhelming detail.Part I of the book, expanded to over 400 pages, comprises in effect a self-contained overview of the Principles of Virology. Part II, entitled Viruses of Humans, deals comprehensively with all the families of human viruses. Extensive coverage is given to the molecular biology of the viruses and of viral replication, pathogenesis and immunity, clinical features of all important diseases caused by all viruses affecting humans, the latest laboratory diagnostic methods, epidemiology and control, including chemotherapy and vaccines.This lucid and concise yet comprehensive text is admirably suited to the needs not only of advanced students of science and medicine but also particularly of postgraduate students, teachers, and research workers in all areas of virology. Key Features* Molecular biology of viruses and viral replication* Pathogenesis and immunity* Latest laboratory diagnostic methods* Clinical features of human viral diseases* Vaccines and chemotherapy* Epidemiology and control

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11/25/2011

Basic Neurochemistry, Seventh Edition: Molecular, Cellular and Medical Aspects Review

Basic Neurochemistry, Seventh Edition: Molecular, Cellular and Medical Aspects
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For anyone interested in neuroscience, it is a must read. Basic Neuroscience gives a snapshot of where neuroscientists are currently doing research, including the edge of what is known and not known. Much of this knowledge has only been discovered in the last few years.

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