Molecular Biology of the Gene, Fifth Edition Review

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(More customer reviews)I am a layman with a serious interest in biology. I read science news, especially in Nature and Scientific American, and I often find that I don't have enough background to understand articles at the level at which I want to understand them. I bought this book hoping to get that background, and I wasn't disappointed.
For example, once the human genome was sequenced, it appeared that there were far too few genes for an organism as complex as ourselves. But investigation shows that most genes occur in segments and that the messenger RNA must be cut and spliced before the protein can be formed. Often there are two or more ways the RNA may be spliced, so that one gene can specify more than one protein. Another problem is that the genome seemed to consist mostly of sections that don't code for proteins; these were called "junk". But it turns out that some "junk" DNA codes for RNA sequences that have catalytic and regulatory roles, roles which used to be considered the bailiwick of proteins alone. Articles about topics such as these used to confuse me thoroughly, but after reading this book I find them much clearer.
This book benefits from a great many illustrations and I recommend that you go through each one as you would a worked problem in a math text. Observe how the pieces fit together, how a particular group of atoms enhances or inhibits a reaction. The practice will help you to understand other things you will read later.
I called this a "reference" for good reason: I assume that I will come across many future articles which will send me back to it to fill in some background.
[Added 4 July 2006] As I assumed when I first wrote this review, I have used it for reference. I have read several books about what I call "enhanced evolution", where mechanisms that go beyond simple point mutations speed up evolution by providing more variation. For example, gene regulation, alternate splicing, and gene duplication all play important roles. I have surprised myself by remembering more than I expected to (thanks to the clarity of this book) but I have still used it for clarification.

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The long-awaited new edition of James D. Watson's classic text, Molecular Biology of the Gene, has been thoroughly revised and is published to coincide with the 50th anniversary of Watson and Crick's paper on the structure of the DNA double-helix. Twenty-one concise chapters, co-authored by five highly respected molecular biologists, provide current, authoritative coverage of a fast-changing discipline, giving both historical and basic chemical context. Divided into four parts: Genetics and Chemistry, Central Dogma, Regulation, and Methods. For college instructors, students, and anyone interested in molecular biology and genetics.

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