Showing posts with label biophysics. Show all posts
Showing posts with label biophysics. Show all posts

3/17/2012

Nanoneuroscience: Structural and Functional Roles of the Neuronal Cytoskeleton in Health and Disease (Biological and Medical Physics, Biomedical Engineering) Review

Nanoneuroscience: Structural and Functional Roles of the Neuronal Cytoskeleton in Health and Disease (Biological and Medical Physics, Biomedical Engineering)
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This book offers an introduction to Nanoneuroscience which is a rather new scientific discipline, drawing on a multitude of foundations and assimilating them into a coherent conceptual framework with a practical scientific program. The authors have managed to carry this nontrivial task in a concise and readable book, which should be accessible to any reader equipped with essential scientific skills and motivation. Each of the chapters is accompanied by an extensive list of references which the reader may explore to gain stronger grasp of the subject matter.
The interested reader may use Amazon's 'look inside' and 'search inside' facilities to get a fairly detailed view of the book's contents. A very short description of the book's chapters should be in place, though.
The first chapter introduces Nanoneuroscience as a distinct discipline, offering a glance into the main concepts which are further revealed in later chapters.
The second chapter discusses the nanoscale components of neurons in varying resolution, ranging from biomolecules to nanodevices.
The third chapter presents the cytoskeleton as a nanoscale information processor.
The fourth chapter introduces the issues of nanocarriers and intracellular transport.
The fifth chapter deals with nanotechnology, nanostructure, and nervous system disorders, which seem to offer some promising applications for Nanoneuroscience.
The sixth chapter concludes the book, surveying novel modes of neural computation, which may someday advance our understanding from nanowires to mind.
Personally speaking, my original main interest was in the sixth chapter, which deals with some admittedly speculative issues, like the adequacy of quantum computational models in future explanations of mental issues, up to consciousness itself. The authors have managed to cover those potentially polemic issues in a factual and sober manner. The rigorous scientific minded reader, however, will find proper coverage on a variety of interesting novel concepts throughout the book. At the core of those issues stand the authors' Intraneuronal Matrix model, including the roles of the neuronal cytoskeleton in health and disease (as adequately hinted by the book's title).
Concluding this short review, I think this book duly deserves the maximal positive rating (five stars).

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Nanoneuroscience is the study of computationally relevant biomolecules found inside neurons. Because of recent technological advances at the nanometer scale, scientists have at their disposal increasingly better ways to study the brain and the biophysics of its molecules. This book describes how biomolecules contribute to the operations of synapses and perform other computationally relevant functions inside dendrites. These biomolecular operations considerably expand the brain-computer analogy - endowing each neuron with the processing power of a silicon-based multiprocessor. Amazingly, the brain containshundreds of billions of neurons.

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1/11/2012

Physics of the Human Body (Biological and Medical Physics, Biomedical Engineering) Review

Physics of the Human Body (Biological and Medical Physics, Biomedical Engineering)
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This book is loaded with technical and grammatical errors. Used if for a course I took essentially just for some of the textbook problems. Definitely not worth the price.

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This book comprehensively addresses the physical and engineering aspects of human physiology by using and building on first-year college physics and mathematics. It is the most comprehensive book on the physics of the human body, and the only book also providing theoretical background. The book is geared to undergraduates interested in physics, medical applications of physics, quantitative physiology, medicine, and biomedical engineering.

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1/08/2012

The Physics of Proteins: An Introduction to Biological Physics and Molecular Biophysics (Biological and Medical Physics, Biomedical Engineering) Review

The Physics of Proteins: An Introduction to Biological Physics and Molecular Biophysics (Biological and Medical Physics, Biomedical Engineering)
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This is an interesting book on a very fascinating subject, the physics of proteins. The book, however, is not a standard text but a compilation of notes for a course on Biological Physics given by Professor Frauenfelder at the University of Illinois. The main topics treated by this book are the structural, energetic, and dynamic properties of proteins, with specific examples on myoglobin, the oxygen-transporter protein which Frauenfelder and coworkers have investigated across several years. On page 178 (chapter 15) I found an interesting discussion about protein quakes, which are concerned with the sudden release of bonding energy in proteins; as an example the authors discuss the breaking of the Fe-CO bond in myoglobin which triggers a quake with an energy release of about 100 kJ/mol (on a relative scale, this is much more powerful than an earthquake!). Another interesting information can be found in Chapter 20 (Thermodynamics for Physicists) where protein fluctuations are discussed: the smaller a system is, the broader its gaussian-like energy distribution. Proteins are large molecules but in comparison to whole cells they are quite small and hence they energy fluctuations can be calculated from the Boltzmann's principle. Each chapter ends with a list of useful references which can be consulted to deepen one's knowledge. As far as I understand, most figures come either from the original notes of the course or from published papers; some figures, however, do not show a good contrast (e.g. Fig. 18.7 on page 252) and the authors could have improved the quality of such figures (given the book's price). This book's brother is "Protein Physics: A Course of Lectures" by Professors Finkelstein and Ptitsyn, two leading exponents of the Russian school of protein physics. Those, like me, that possess both books will appreciate the different styles adopted by the American and Russian schools of biophysics as well as learn a lot of interesting physics that goes on inside proteins.

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10/31/2011

Medical Physiology: With STUDENT CONSULT Online Access (MEDICAL PHYSIOLOGY (BORON)) Review

Medical Physiology: With STUDENT CONSULT Online Access (MEDICAL PHYSIOLOGY (BORON))
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I have bought 4 physiology books during my medical studies and i am only a second year student! And i must say, that this book is definetely the best one, if you have the basic knowledge. If you are a new begginer though, it is very very difficult to start with this book, since the explanations are very detailed and require a certain level of 'scientific way of thinking'. There are many research examples and historical links, something that a student prepearing for an exam doesn't want to waste time on. Some of the explanations are too long and complicated, that one looses the initial idea of what the explanation was about.
On the other hand, if you are quite skilfull in physiology, this is a great book. The pictures are extraordinary and very scematic and understandable!!! You definetely get a lot for your money!
So, in conclusion, if you buy yourself a simpler physiology book and get the basics from there, Medical Physiology is the perfect choise to go on expanding your knowledge with. But don't buy it as your very very first physiology book. It will just confuse and frustrate you.

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