Showing posts with label any job market. Show all posts
Showing posts with label any job market. Show all posts

8/24/2012

Death Foretold: Prophecy and Prognosis in Medical Care Review

Death Foretold: Prophecy and Prognosis in Medical Care
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Death Foretold is an exceptional book. Effortlessly blending history, sociology and clinical acumen, it tells the story of how and why doctors (sometimes) avoid answering the one question their patients really need the answer to: "So what does this mean for me?". It marshalls an impressive array of data, from wonderfully human qualitative interviews with physicians, to rigorously executed quantitative experiments and surveys. All is explained in an elegant and eminently readable voice deeply sympathetic to the patients undergoing awful disease, the families caring for them, and the physicians charged with helping. This is a book that any one training (or trained) in the healing arts must read; but it is also a rare and wonderful chance for those who may one day be patients nearing death to gain some insight into what that experience is like -- and the rich possibilities it could also have.

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7/09/2012

Inborn Metabolic Diseases: Diagnosis and Treatment Review

Inborn Metabolic Diseases: Diagnosis and Treatment
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I'm now into the vast subject of inherited metabolic diseases for about one and a half year. This book is the perfect guide in dayly clinical work. It gives a short introduction at the first page of every chapter, showing the metabolic pathway and giving a short summery of the different types of metabolic defects in this part of metabolism. It's not only brief but also based on the recent publications. The very systematic structure and the much better index of this new edition is another reason why there is no day without Fernandez et al. in my clinical work.

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2/27/2012

Inhuman Research: Medical Experiments in German Concentration Camps Review

Inhuman Research: Medical Experiments in German Concentration Camps
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Alfred Pasternak's monumental work, "Inhuman Research" is an extraordinary accommplishment. The author has gleaned extremely difficult to obtain data on this sad period in human history, and has presented it very effectively: "shocking" is a masterpiece of understatement. Only someone who has either experienced these horrors, or been in close proximity to those who have, could tell this tragic story of a very shameful period in the history of humanity.

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2/21/2012

Spasticity: Diagnosis and Management Review

Spasticity: Diagnosis and Management
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First, a bit of a disclaimer; I have coauthored an article with one of the two primary authors (1). Also, this book is published by the same publisher as my book, Stronger After Stroke.
There are great reasons to have this book. Much of the book I've yet to digest (the book is nearly 350 large pages). But everywhere I turn, I learn something new. The section on Chemoneurolysis has an amazing breakdown of the cost of phenol vs. more expensive nerve blocks. Ch. 14 ("Emerging technologies...") with its emphasis on reestablishment of cortical control is worth the price of admission. Thomas Watenabe's chapter is concise and well written. The photographs throughout are instructive.
Please note the following LONG paragraph is specifically about chapter 13, my primary area of interest.
Much of chapter 13 (The Role of PT/OT) is a scatter-shot of reviews of journal articles. On more than one occasion the authors include research on devices purported to reduce spasticity that are coauthored by people with a financial COI. Editing issues in Ch. 13: The sentence "The intensity of the stretch provided can be modulated by controlling the ankle at which the table is set at." The dangling "at" and "ankle" for "angle" is an issue of editing that should have been picked up by the publisher. (Authors, please note; in the article by Bakhtiary (2) there was no NMES-only group). The Ashworth, a test (for the sake of brevity) of resistance of soft tissue, is discussed in this chapter, as well. The Ashworth scale is available in this chapter, as well as in several other chapters. The authors of Ch 13 state that there are no "...standardized procedures for patient positioning, scoring, or overall test implementation." Still, having used the Ashworth in many clinical trials, there's at least one truth: A baseline score may be best garnered in supine. Just as baseline BP is best garnered at rest, baseline testing of spasticity is also best measured at rest. Everything that falls under the category of "spasticity" (resistance to stretch, hyperreflexia, etc.) is reduced in supine because contraction of muscles, including the trunk muscles during sitting, will increase the score. The varying amounts of muscle contraction needed by different people during sitting provides a clear confound to standardization. There is a portion on stretching which the authors rightly suggest is over-rated as a hedge against the long term effects of spasticity. It would have been helpful to include mention the article (a systematic review) that best drives this point home (3). I should point out that Watenabe's article (4) which appears to also have had great impact on Ch. 13, has significantly guided my perspective on spasticity and its reduction. For clinicians involved in OT and PT, I'd suggest that article as a serious tool for helping patients.
But, again, this is an essential book for anyone treating or testing and spasticity. One reason to own it is that, because its focus is pristine (in this regard, its stands alone) it provides the only comprehensive perspective in print. It manages to span the width and breadth of the complexity of spasticity. For instance, there's a whole section on assessing spasticity. For clinicians treating spasticity, assessment tools that provide quantifiable data are essential because without quantifiable data treatment efficacy is questionable.
There are chapters on spasticity as it affects SCI, MS, stroke, TBI and more. There's a section on treatment, measurement and the basic science of spasticity.
This book manages to be both highly technical and highly readable. Tons of clichés come to mind; it's a must-have; it's an essential book; it's the only book of its kind.
1.Page SJ, Elovic E, Levine P, Sisto SA. Modified constraint-induced therapy and botulinum toxin A: a promising combination. Am J Phys Med Rehabil 2003 Jan;82(1):76-80.
2.Bakhtiary AH, Fatemy E. Does electrical stimulation reduce spasticity after stroke? A randomized controlled study. Clin Rehabil. 2008 May;22(5):418-25.
3.Bovend'Eerdt TJ, Newman M, Barker K, Dawes H, Minelli C, Wade DT. The effects of stretching in spasticity: a systematic review. Arch Phys Med Rehabil. 2008 Jul;89(7):1395-406. Epub 2008 Jun 13. Review. PubMed PMID: 18534551.
4.Watanabe T. The role of therapy in spasticity management. Am J Phys Med Rehabil. 2004 Oct;83(10 Suppl):S45-9. Review. PubMed PMID: 15448577.

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1/08/2012

The Physics of Proteins: An Introduction to Biological Physics and Molecular Biophysics (Biological and Medical Physics, Biomedical Engineering) Review

The Physics of Proteins: An Introduction to Biological Physics and Molecular Biophysics (Biological and Medical Physics, Biomedical Engineering)
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This is an interesting book on a very fascinating subject, the physics of proteins. The book, however, is not a standard text but a compilation of notes for a course on Biological Physics given by Professor Frauenfelder at the University of Illinois. The main topics treated by this book are the structural, energetic, and dynamic properties of proteins, with specific examples on myoglobin, the oxygen-transporter protein which Frauenfelder and coworkers have investigated across several years. On page 178 (chapter 15) I found an interesting discussion about protein quakes, which are concerned with the sudden release of bonding energy in proteins; as an example the authors discuss the breaking of the Fe-CO bond in myoglobin which triggers a quake with an energy release of about 100 kJ/mol (on a relative scale, this is much more powerful than an earthquake!). Another interesting information can be found in Chapter 20 (Thermodynamics for Physicists) where protein fluctuations are discussed: the smaller a system is, the broader its gaussian-like energy distribution. Proteins are large molecules but in comparison to whole cells they are quite small and hence they energy fluctuations can be calculated from the Boltzmann's principle. Each chapter ends with a list of useful references which can be consulted to deepen one's knowledge. As far as I understand, most figures come either from the original notes of the course or from published papers; some figures, however, do not show a good contrast (e.g. Fig. 18.7 on page 252) and the authors could have improved the quality of such figures (given the book's price). This book's brother is "Protein Physics: A Course of Lectures" by Professors Finkelstein and Ptitsyn, two leading exponents of the Russian school of protein physics. Those, like me, that possess both books will appreciate the different styles adopted by the American and Russian schools of biophysics as well as learn a lot of interesting physics that goes on inside proteins.

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